# ToxIndex vs the OECD QSAR Toolbox

> How using the OECD QSAR Toolbox on its own compares to running it inside ToxIndex, with curated data, additional tools, and orchestrated workflows.

> ToxIndex integrates the OECD QSAR Toolbox rather than replacing it, so this compares running the Toolbox by hand in its desktop app with running the same engine inside an orchestrated assessment that adds curated data, more tools, and a reproducible audit trail.

## Side-by-side comparison
| Capability | ToxIndex | The OECD QSAR Toolbox alone |
|---|---|---|
| Read-across engine | The full OECD QSAR Toolbox 4.8 — 57 endpoints, 244 validated models, 79 profilers — run for you | The full OECD QSAR Toolbox 4.8, driven by hand in the desktop application |
| Data behind a substance | 356 curated databases and 90M+ regulatory documents alongside the Toolbox's own | The databases bundled with the Toolbox |
| Tools | 100+ additional validated tools, including open-source ToxTransformer | The Toolbox's QSAR models |
| Orchestration | Read-across runs as one step in an automated assessment workflow | Manual, step-by-step in the GUI |
| Reproducibility | Versioned data snapshot and model versions; a run reproduces identically | Depends on the analyst's saved session |
| Interface | Ask in plain language; Sage returns the result with citations | Expert-driven desktop application |
| Deployment | Cloud or air-gapped, with the Toolbox integrated and maintained | A free desktop install you run and maintain yourself |

The OECD QSAR Toolbox is the regulatory reference for chemical grouping and structure-activity read-across. Regulators expect to see it, and ToxIndex runs on the same engine. The point of this comparison is not which tool is better, but whether you need anything around the Toolbox to get a dossier done.

## What the Toolbox does well

The Toolbox is free, thorough, and accepted. It profiles a structure for mechanistic and metabolic alerts, groups analogs the way ECHA's framework asks for, and generates read-across with a justification a regulator will review. For a toxicologist who knows it well, it is a capable desktop tool.

## What ToxIndex adds around it

Running the Toolbox by hand is one step of an assessment, not the whole assessment. You still have to gather what is already known about a substance, decide which endpoints need filling, run the read-across, and assemble the result into something defensible, then repeat it for every substance in a portfolio.

ToxIndex keeps the Toolbox as the read-across engine and wraps the rest around it. Curated data resolves each substance against 356 databases before you group anything. Where the Toolbox's models do not cover an endpoint, 100+ additional tools do. Read-across becomes a step in an automated workflow rather than a manual session, and the whole run keeps a versioned audit trail, so it reproduces exactly when a reviewer asks a year later.

## When the standalone Toolbox is enough

If you assess a handful of substances a year, already know the Toolbox, and do your data gathering separately, the free desktop application may be all you need. ToxIndex earns its place when the volume grows, when you need curated data and tools in the same run, or when reproducibility and a single plain-language interface matter across a team.

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Canonical page: https://toxindex.com/compare/qsar-toolbox