# Pleiome — Generative multi-property transformer

> One model, 150,000+ endpoints, run in both directions.

Pleiome is the generative successor to ToxTransformer, in development. It predicts 150,000+ ADMET, toxicological, and biochemical endpoints in a single pass — 22.5x ToxTransformer's coverage — trained on the entire Yard knowledge graph rather than a subset. Run it forward to score a molecule, or backward to design one: give it a target safety profile and it generates novel, synthesizable structures.

## Key facts
- **150,000+** — endpoints predicted at once
- **22.5x** — the endpoint coverage of ToxTransformer
- **0.942** — mean AUROC on the ToxBench core tasks

## What Pleiome does

### Predicts broadly
One transformer covering 150,000+ ADMET, toxicological, and biochemical endpoints in a single pass, each with a confidence you can weigh.

### Design, don't just screen
Run in reverse: give it a target profile and it proposes novel, synthesizable structures, optimizing multiple objectives at once.

### Trained on the whole graph
Learns from the entire Yard knowledge graph, giving it far more signal than the public data most models see.

## How it works
1. **Predict** — Score a molecule across 150,000+ endpoints in a single pass, each with a confidence you can weigh.
2. **Compare** — Read predictions beside measured data from Kiln and automated OECD read-across from ToxJobs.
3. **Design** — Invert the model to generate candidate structures that meet a target ADMET and toxicity profile.

## Works closely with
- [ToxTransformer](https://toxindex.com/platform/toxtransformer.md): Open-source molecular toxicity model
- [Yard](https://toxindex.com/platform/yard.md): Raw data warehouse
- [ToxJobs](https://toxindex.com/platform/toxjobs.md): Prediction toolkit

## Frequently asked questions

**What is Pleiome?**

Pleiome is a generative transformer trained on the Yard knowledge graph that predicts 150,000+ endpoints at once and can run inverse design to hit a target safety profile. It is in development.

**How much more does Pleiome cover than ToxTransformer?**

Pleiome predicts 150,000+ endpoints at once — 22.5x ToxTransformer's coverage — while holding 0.942 mean AUROC across the ToxBench core tasks.

**What is inverse molecular design?**

Instead of scoring a molecule you already have, you give Pleiome a target ADMET and toxicity profile and it generates novel, synthetically accessible structures that meet it, optimizing several objectives at once.

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Canonical page: https://toxindex.com/platform/pleiome