# Chemicals & energy — Industrial chemicals > Register and steward a portfolio without assessing each substance by hand. Industrial chemical and energy portfolios run into the hundreds or thousands of substances, each with REACH, TSCA, and international obligations. ToxIndex turns per-substance assessment from a manual grind into a repeatable pipeline. ## The portfolio doesn't scale by hand When you steward hundreds of substances, the manual approach breaks: you cannot assess each one at the depth regulators expect, track which endpoints each tonnage band requires, and keep up as guidance shifts underneath you. ToxIndex handles the gathering and prediction across the whole portfolio, knows the data requirements per tonnage band, and flags which existing assessments a guidance change touches, so stewardship becomes maintenance, not re-litigation. ## Key facts - **Portfolio** — scale gathering and prediction - **60+** — endpoints at the top tonnage band - **1,000+** — regulatory sources monitored ## What ToxIndex covers for chemicals & energy ### Registration at scale Run REACH and TSCA support across a portfolio, with tonnage-band awareness for what each substance requires. ### Find the gaps across the book Gaps maps dossiers to endpoints and flags what is missing, so you triage a whole portfolio instead of guessing. ### Stay ahead of guidance Crawler monitors regulatory sources and flags which existing assessments a change affects. ### Rerun when the rules move Flow reruns any historical assessment against updated requirements and shows exactly what changed. ## Related platform tools - [Gaps](https://toxindex.com/platform/gaps.md): Automated data-gap analysis - [Crawler](https://toxindex.com/platform/crawler.md): Regulatory document search engine - [ToxJobs](https://toxindex.com/platform/toxjobs.md): Prediction toolkit - [Flow](https://toxindex.com/platform/flow.md): Reproducible workflow engine ## Related solutions - [REACH registration](https://toxindex.com/solutions/reach-compliance.md): REACH & CLP - [Data gap analysis](https://toxindex.com/solutions/data-gap-analysis.md): Dossier coverage - [Internal safety teams](https://toxindex.com/solutions/internal-safety-teams.md): In-house toxicology ## Frequently asked questions **Can ToxIndex handle a portfolio of hundreds of substances?** Yes. It runs gathering and prediction across the whole portfolio, knows the data requirements per tonnage band, and flags which existing assessments a guidance change touches. **What happens when guidance changes?** Flow reruns any historical assessment against updated requirements and shows exactly what changed, so keeping a portfolio current is routine upkeep. **How many regulatory sources are monitored?** Crawler monitors 1,000+ regulatory sources for the changes that affect your book. --- Canonical page: https://toxindex.com/solutions/chemicals-energy