Evidence-based AI for chemical safety
Empowered scientists. Accelerated research.
Thousands of databases, millions of documents, hundreds of tools. One platform.
Try Sage for free and get access to all of ToxIndex's resources. Book a demo to learn more about workflow automation.
Download a sample assessment- 2,000+
- databases
- 100B+
- data points
- 90M+
- regulatory & scientific documents
- 100+
- computational tools
The capacity crisis
Demand for chemical assessments has outpaced what experts can handle.
ToxIndex automates literature synthesis, predictive modeling, and draft compilation, so toxicologists spend their hours on expert judgment instead of data entry.
- 86,000
- registered commercial chemicals.
- ~9,000
- certified North American toxicologists.
- 88%
- of all EPA reviews delayed.
The platform
Interactive or automated.
Access every ToxIndex resource through two tailored interfaces.
Ask
Sage
Conversational orchestrator
Ask a chemical or biological question in plain language and receive a grounded, cited answer. When experimental data is unavailable, Sage executes the necessary, validated predictive models.
Execute
Flow
Structured orchestrator
Run a structured workflow, including risk assessments, with complete reproducibility. Generate version-locked audit trails and dossiers that withstand rigorous regulatory audits.
Data provenance
Observable, traceable, verifiable.
Every fact and claim, whether it comes from literature, a curated database, a regulatory document, or a computational tool, links directly to its atomic source: a cell in a database, a sentence in a document, or a versioned model.
Explore atomic-source traceabilityTrack record
A decade of computational toxicology.
For over ten years, Insilica has built peer-reviewed computational biology and toxicology platforms for enterprise and federal agencies. Funded by NIH and NSF grants, our systems are built for scientific accuracy and rigorous audit compliance.
Review grants & publications
AI-accelerated systematic review — in production since 2019, 94M+ relevance predictions.
Peer-reviewed open-data registry — 90+ curated, versioned datasets.
We built 3 of the core AI tools in this €17.2M EU consortium for animal-free chemical assessment.
Built under NIH and NSF grants and an FDA Phase III production contract.
Solutions
Tailored to your needs.
ToxIndex supports multiple entry points depending on your compliance targets, industry regulations, and operational structure.
By assessment
Accelerate REACH registrations and IUCLID dossiers, new-chemical hazard screenings, ICH M7 impurity evaluations, data-gap analyses, or custom artifacts.
By sector
Comply with industry- and regulatory-environment-specific requirements. Pharma, cosmetics, agriculture, consumer products, and energy — US, EU, or global.
By structure
Corporate and pre-clinical toxicology, CROs, and consultancies get more done with ToxIndex without sacrificing accuracy and rigor.
Flexible deployment
Our cloud, your cloud, or air-gapped.
Encrypted end to end, with SOC 2 and ISO 27001 audits underway. For bring-your-own-cloud (BYOC) and on-premises deployments, your proprietary chemical structures never leave your environment.
See how we handle your dataFrequently asked questions
What is ToxIndex?
An agentic platform for computational toxicology. Ask a chemical safety question and get a cited answer, or run a reproducible assessment workflow, both on a foundation of curated data, a regulatory document index, and validated tools.
How does Sage answer questions?
Sage searches curated databases, regulatory documents, and chemical lists, and runs predictors where a study is missing. Every statement links back to the study, document, or prediction behind it, so you can verify the reasoning.
Can I run it without my chemistry leaving my environment?
Yes. On GCP you can deploy ToxIndex into your own project in one click, straight from the Google Cloud Marketplace as a Kubernetes (GKE) app, with the packaging and orchestration already done for you. On other clouds we set it up with you, and on-premises we support fully air-gapped operation. In BYOC and on-prem deployments, your chemical structures never leave your environment.
Which regulatory frameworks does it cover?
ToxIndex integrates EU repositories — ECHA REACH, the C&L Inventory, SCCS, EFSA OpenFoodTox, CosIng — alongside US frameworks (EPA, FDA, OSHA) and others including Health Canada, K-REACH, Japan CSCL, and Australia AICIS.
How do you handle security?
Data is encrypted at rest and in transit on Google Cloud. Our SOC 2 and ISO 27001 audits are in progress, and we maintain a public Trust Center. See the Trust page for the full picture.
See it on your own chemistry.
Try the free version now, or book a walkthrough of the full platform on your substances.