Solutions · By job to be done
Compress a REACH dossier from quarters to weeks.
A registration at the 10–100 tonne band needs roughly 30 endpoints, and above 1,000 tonnes you are looking at 60+. ToxIndex gathers what is already known, flags what is missing, and keeps the reasoning traceable end to end so the dossier holds up.
Updated July 18, 2026
- 60+
- endpoints at the top tonnage band
- 90M+
- regulatory documents searched
- 244
- OECD-validated QSAR models for read-across
The situation
The data-gathering problem
Most of a REACH timeline disappears before anyone fills a single gap. Finding what is already known means searching ECHA REACH dossiers, the C&L Inventory, EFSA OpenFoodTox, national databases, and the published literature — weeks of manual work per substance, repeated for every entry in a portfolio.
ToxIndex draws that evidence from a curated foundation instead of a browser tab. Hazard data arrives organized by endpoint and linked back to the study and regulatory decision it came from, so what you assemble is defensible from the first draft.
How ToxIndex helps
What ToxIndex does for a registration
Gather known hazard data
Kiln resolves each substance against 356 curated databases and returns evidence by endpoint, cross-linked and cited, so you work from organized findings instead of a stack of PDFs.
Read-across the regulator expects
The OECD QSAR Toolbox handles grouping and structure-activity read-across the way ECHA's framework asks for it, with mechanistic justification attached.
Fill gaps with documented predictions
Where no study exists, run validated predictors that come with confidence and an applicability-domain read, so you know where the ground is solid.
See what a dossier still misses
Gaps maps an IUCLID dossier to its endpoints and flags the ones with no supporting study, before a compliance check does.
How it works
From input to defensible result
- 1
Assemble the evidence
Point ToxIndex at your substance and it pulls curated data and regulatory documents into a structured, cited picture by endpoint.
- 2
Close the gaps
Run read-across and predictors for the endpoints without a study, each carrying its own justification.
- 3
Keep it reproducible
Flow records the data snapshot, model versions, and steps, so you can rerun the assessment when guidance changes and see exactly what moved.
The tools behind it
What runs underneath
FAQ
Questions teams ask
Frequently asked questions
How long does a REACH dossier take with ToxIndex?
Most of a REACH timeline is data gathering, not gap filling. ToxIndex pulls known hazard data from a curated foundation instead of manual searches across ECHA, the C&L Inventory, and the literature, compressing weeks of assembly per substance into a structured, cited picture by endpoint.
How many endpoints does a REACH registration need?
A registration needs roughly 30 endpoints at the 10–100 tonne band and 60+ at the top tonnage band above 1,000 tonnes. ToxIndex flags which of them your dossier still misses.
Is ToxIndex read-across acceptable to ECHA?
Read-across runs through the OECD QSAR Toolbox — the regulatory reference for grouping and structure-activity read-across — with mechanistic justification attached, so it comes in the form ECHA expects to review.
See it on your own chemistry.
Try the free version now, or book a walkthrough of the full platform on your substances.